Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, PT-141 is FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and is studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways42101.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, PT-141 is the synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal3242101.
Matrixyl
Not assigned in the current dataset.
PT-141
POMC
Matrixyl and PT-141 are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Matrixyl is more often discussed in the realm of Dermatology and aesthetics, whereas PT-141 is more often associated with the realm of Reproductive health. They also influence different molecular systems, with Matrixyl tracking more closely to Extracellular matrix proteins while PT-141 centers more on GPCR receptor. Matrixyl has a more synthetic design origin, while PT-141 is closer to synthetic analog background and their development context also differs, with Matrixyl cosmetic grade while PT-141 is approved. Matrixyl takes the form of a peptide conjugate, whereas PT-141 is closer to a cyclic peptide, while Matrixyl carries palmitoylation features, while PT-141 instead reflects acetylation changes.
No related articles are linked to these peptides yet.