Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, MOTS-c improves insulin sensitivity, enhances glycolysis, reduces oxidative stress, and shows protective effects in models of metabolic syndrome, aging, and ischemia-reperfusion injury8135146.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, MOTS-c is a 16-amino-acid mitochondrial-derived peptide that translocates to the nucleus under metabolic stress and regulates glucose and lipid metabolism largely via activation of AMPK and modulation of mTOR and folate-cycle–linked pathways854140146.
Matrixyl
Not assigned in the current dataset.
MOTS-c
MT-RNR1
Matrixyl and MOTS-c are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Matrixyl is more often discussed in the realm of Dermatology and aesthetics, whereas MOTS-c is more often associated with the realm of Metabolic and endocrine and Aging and longevity. They also influence different molecular systems, with Matrixyl tracking more closely to Extracellular matrix proteins while MOTS-c centers more on Mitochondrial membrane. Matrixyl has a more synthetic design origin, while MOTS-c is closer to mitochondrial-encoded background and their development context also differs, with Matrixyl cosmetic grade while MOTS-c is in Preclinical development. Matrixyl takes the form of a peptide conjugate, whereas MOTS-c is closer to a linear peptide, Matrixyl incorporates palmitoylation features that are not part of MOTS-c; while their sequence patterns also diverge, with Matrixyl showing protein-mimetic sequence features and MOTS-c showing hydrophobic domain features.
No related articles are linked to these peptides yet.