Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48, Melanotan II is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans3545.
While Matrixyl works as a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858, Melanotan II is a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior3545.
Matrixyl
Not assigned in the current dataset.
Melanotan II
POMC
Matrixyl and Melanotan II are noticeably different, with limited direct overlap in their usual biological context. Both are often discussed in Dermatology and aesthetics contexts, while Matrixyl is more of a matrikine and Signal peptide and Melanotan II is better described as a hormone peptide and Neuropeptide. They also influence different molecular systems, with Matrixyl tracking more closely to Extracellular matrix proteins while Melanotan II centers more on Melanocortin receptor. Matrixyl has a more synthetic design origin, while Melanotan II is closer to synthetic analog background and their development context also differs, with Matrixyl cosmetic grade while Melanotan II is approved for Research use only. Matrixyl takes the form of a peptide conjugate, whereas Melanotan II is closer to a cyclic peptide, while Matrixyl carries palmitoylation features, while Melanotan II instead reflects acetylation changes.
No related articles are linked to these peptides yet.