Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While LL-37 acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.
While LL-37 works as a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.
LL-37
CAMP
Matrixyl
Not assigned in the current dataset.
LL-37 and Matrixyl are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: LL-37 is more often discussed in the realm of Immunology and inflammation and Gastroenterology, whereas Matrixyl is more often associated with the realm of Dermatology and aesthetics. They also influence different molecular systems, with LL-37 tracking more closely to GPCR receptor while Matrixyl centers more on Extracellular matrix proteins. LL-37 has a more natural endogenous origin, while Matrixyl is closer to synthetic design background and their development context also differs, with LL-37 in Preclinical development while Matrixyl is cosmetic grade. LL-37 takes the form of a linear peptide, whereas Matrixyl is closer to a peptide conjugate, Matrixyl incorporates palmitoylation features that are not part of LL-37; while their sequence patterns also diverge, with LL-37 showing cationic amphipathic and alpha-helical domain features and Matrixyl showing protein-mimetic sequence features.
No related articles are linked to these peptides yet.