Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While KPV is investigated as an anti-inflammatory and barrier-protective agent in skin and mucosal models, reducing pro-inflammatory cytokines and promoting tissue repair684, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.
While KPV works as the C-terminal Lys-Pro-Val tripeptide fragment of α-MSH, which exerts potent anti-inflammatory effects largely via inhibition of NF-κB signaling and modulation of cytokine expression, with many actions independent of classical melanocortin receptor activation684, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.
KPV
POMC
Matrixyl
Not assigned in the current dataset.
Both peptides fall into a similar broad context as Signal peptides, although the details of how they are used and discussed still diverge. Both are often discussed in Dermatology and aesthetics contexts, while KPV is more of a immune-modulating peptide and Matrixyl is better described as a matrikine. They also influence different molecular systems, with KPV tracking more closely to Melanocortin receptor while Matrixyl centers more on Extracellular matrix proteins. KPV has a more natural endogenous origin, while Matrixyl is closer to synthetic design background and their development context also differs, with KPV in Preclinical development while Matrixyl is cosmetic grade. KPV takes the form of a linear peptide, whereas Matrixyl is closer to a peptide conjugate, while Matrixyl incorporates palmitoylation features that are not part of KPV.
No related articles are linked to these peptides yet.