Comparison
While Ipamorelin is investigated for producing moderate, physiologic-like GH pulses useful for studying anabolic, body-composition, and recovery effects with a relatively clean endocrine side-effect profile compared with earlier GHRPs16, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Ipamorelin works as a third-generation pentapeptide growth hormone secretagogue that selectively agonizes the ghrelin (GHSR-1a) receptor to trigger controlled, GH-specific pituitary release with minimal effects on cortisol or prolactin16269596, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Ipamorelin is 5 amino acids long, whereas SS-31 is shorter as it has a length of 4 amino acids. Ipamorelin is made up of a sequence of Aib, Histidine, D-2-Nal, Phenylalanine, Lysine. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.
Ipamorelin
GHSR
SS-31
Not assigned in the current dataset.