Comparison

Hexarelin vs MGF

Function

While Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929, MGF is upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects22138.

Mechanism

While Hexarelin works as a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996, MGF is a 24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy22138144.

Length and Sequence

Hexarelin is 6 amino acids long, whereas MGF is longer as it has a length of 24 amino acids. Hexarelin is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine. MGF is made up of a sequence of Tyrosine, Glutamine, Proline, Proline, Serine, Threonine, Asparagine, Lysine, Asparagine, Threonine, Lysine, Serine, Glutamine, Arginine, Arginine, Lysine, Glycine, Serine, Threonine, Phenylalanine, Glutamic acid, Glutamic acid, Arginine, Lysine.

Receptor

Hexarelin

Primary: GHSR-1a (ghrelin receptor); also binds the scavenger receptor CD36 in vascular and macrophage tissues192129

MGF

Insulin-like growth factor 1 receptor (IGF1R) 134139

Organism or Origin

Hexarelin

Fully synthetic growth hormone secretagogue29

MGF

Endogenous human IGF-1 splice variant (IGF-1Ec) 2213897

Gene

Hexarelin

GHSR

MGF

IGF1

Related articles

No related articles are linked to these peptides yet.

Sources

19Identification of the growth hormone-releasing peptide binding site ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC1133797/
21Hexarelin Peptide | Strength & Recovery - Paragon Sports Medicine, https://www.paragonsportsmedicine.com/peptides/hexarelin
29Examorelin - Wikipedia, https://en.wikipedia.org/wiki/Examorelin
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
22Mechano growth factor - Wikipedia, https://en.wikipedia.org/wiki/Mechano_growth_factor
97IGF1 Gene - Insulin Like Growth Factor 1, https://www.genecards.org/cgi-bin/carddisp.pl?gene=IGF1
134Insulin-like growth factor 1 receptor - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1_receptor
138A Splice Variant of IGF-1 within the Growth Plate | PLOS One, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076133
139IGF1 receptor signaling pathways, https://pubmed.ncbi.nlm.nih.gov/29535161/
144Insulin-like growth factor 1 - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1