Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While GHRP-6 is used experimentally to produce strong GH surges and hyperphagia, allowing investigation of GH-dependent anabolism and energy-balance regulation2030, Semax is used clinically in Russia for ischemic stroke and cognitive disorders; in models it improves learning, protects dopaminergic neurons, and modulates stress responses without significant endocrine ACTH-like effects166174.
While GHRP-6 works as a first-generation synthetic hexapeptide ghrelin mimetic that potently stimulates GH release and markedly increases appetite via GHSR-1a activation in hypothalamus and pituitary203096, Semax is a synthetic heptapeptide, Met-Glu-His-Phe-Pro-Gly-Pro (MEHFPGP), that is an analog of ACTH(4–10) with a Pro-Gly-Pro extension and exerts neurotrophic and neuroprotective actions partly via upregulation of BDNF and modulation of dopaminergic and glutamatergic systems40162165174.
GHRP-6
GHSR
Semax
POMC
GHRP-6 and Semax are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: GHRP-6 is more often discussed in the realm of Metabolic and endocrine and Musculoskeletal health, whereas Semax is more often associated with the realm of Neurology and brain health and Ophthalmology. They also influence different molecular systems, with GHRP-6 tracking more closely to Ghrelin receptor while Semax centers more on GPCR receptor. GHRP-6 has a more synthetic design origin, while Semax is closer to synthetic analog background with GHRP-6 in Preclinical development and Semax approved for Research use only. GHRP-6 incorporates d-amino acid substitution and amidation features that are not part of Semax.
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