Comparison

GHRP-6 vs Selank

Function

While GHRP-6 is used experimentally to produce strong GH surges and hyperphagia, allowing investigation of GH-dependent anabolism and energy-balance regulation2030, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.

Mechanism

While GHRP-6 works as a first-generation synthetic hexapeptide ghrelin mimetic that potently stimulates GH release and markedly increases appetite via GHSR-1a activation in hypothalamus and pituitary203096, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.

Length and Sequence

GHRP-6 is 6 amino acids long, whereas Selank is longer as it has a length of 7 amino acids. GHRP-6 is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.

Receptor

GHRP-6

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 203096104

Selank

Not clearly established in the current dataset.

Organism or Origin

GHRP-6

Synthetic peptide analog of met-enkephalin30

Selank

Synthetic analog of the IgG-derived tetrapeptide tuftsin39

Gene

GHRP-6

GHSR

Selank

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

20GHRP-6: The Original GHRP Research Overview - Peptidings, https://peptidings.com/peptides/ghrp-6/
30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
39Application of thr-lys-pro-arg-pro-gly-pro peptide (selank) for ..., https://patents.google.com/patent/RU2629832C1/en