Comparison

GHRP-6 vs Matrixyl

Function

While GHRP-6 is used experimentally to produce strong GH surges and hyperphagia, allowing investigation of GH-dependent anabolism and energy-balance regulation2030, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.

Mechanism

While GHRP-6 works as a first-generation synthetic hexapeptide ghrelin mimetic that potently stimulates GH release and markedly increases appetite via GHSR-1a activation in hypothalamus and pituitary203096, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.

Length and Sequence

GHRP-6 is 6 amino acids long, whereas Matrixyl is shorter as it has a length of 5 amino acids. GHRP-6 is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine. Matrixyl is made up of a sequence of Lysine, Threonine, Threonine, Lysine, Serine.

Receptor

GHRP-6

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 203096104

Matrixyl

Not clearly established in the current dataset.

Organism or Origin

GHRP-6

Synthetic peptide analog of met-enkephalin30

Matrixyl

Synthetic lipopeptide derived from a collagen I C-terminal fragment sequence5158

Gene

GHRP-6

GHSR

Matrixyl

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

20GHRP-6: The Original GHRP Research Overview - Peptidings, https://peptidings.com/peptides/ghrp-6/
30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
48Palmitoyl Pentapeptide-4 - R&D PEPTIDE.ONE, https://rnd.peptide.one/product/palmitoyl-pentapeptide-4-pal-lys-thr-thr-lys-ser/
51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
58[PDF] Safety Assessment of Myristoyl Pentapeptide-4, Palmitoyl ..., https://www.cir-safety.org/sites/default/files/Pentapeptide%20Ingredients.pdf