Comparison

GHRP-2 vs Selank

Function

While GHRP-2 is used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics6272, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.

Mechanism

While GHRP-2 works as a second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol62723096, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.

Length and Sequence

GHRP-2 is 6 amino acids long, whereas Selank is longer as it has a length of 7 amino acids. GHRP-2 is made up of a sequence of Alanine, D-2-Nal, Alanine, Tryptophan, Phenylalanine, Lysine. Selank is made up of a sequence of Threonine, Lysine, Proline, Arginine, Proline, Glycine, Proline.

Receptor

GHRP-2

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 309596104

Selank

Not clearly established in the current dataset.

Organism or Origin

GHRP-2

Synthetic met-enkephalin–derived hexapeptide3072

Selank

Synthetic analog of the IgG-derived tetrapeptide tuftsin39

Gene

GHRP-2

GHSR

Selank

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
62GHRP-2: Potent Growth Hormone Releasing Peptide Guide, https://www.peptidepedia.org/performance/ghrp-2
72GHRP-2 Technical Data - Molecular Specs - Peptide Initiative, https://peptideinitiative.com/peptides/ghrp-2/technical
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
39Application of thr-lys-pro-arg-pro-gly-pro peptide (selank) for ..., https://patents.google.com/patent/RU2629832C1/en