Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While GHRP-2 is used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics6272, Melanotan I is approved in some regions for prevention of phototoxicity in erythropoietic protoporphyria and is studied as a skin-darkening, photoprotective peptide3444.
While GHRP-2 works as a second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol62723096, Melanotan I is a linear 13-amino-acid analog of α-MSH (afamelanotide) that selectively activates MC1R on melanocytes, increasing eumelanin synthesis and providing photoprotection3444.
GHRP-2
GHSR
Melanotan I
POMC
Both peptides fall into a similar broad context as Hormone peptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: GHRP-2 is more often discussed in the realm of Metabolic and endocrine and Musculoskeletal health, whereas Melanotan I is more often associated with the realm of Dermatology and aesthetics. Both appear to work through Receptor agonist, but the functional emphasis still separates, with GHRP-2 leaning toward Anabolic growth and Lipolysis and fat loss and Melanotan I leaning toward Melanogenesis modulation. GHRP-2 has a more synthetic design origin, while Melanotan I is closer to synthetic analog background with GHRP-2 in Clinical phase 1 and Melanotan I approved for Research use only. They are also usually discussed through the same administration routes, namely subcutaneous injection.
No related articles are linked to these peptides yet.