Comparison

GHK-Cu vs Melanotan II

Function

While GHK-Cu acts as a tissue-remodeling and wound-healing signal, enhancing skin regeneration, angiogenesis, and repair while reducing inflammation and oxidative damage in experimental models31383, Melanotan II is studied as a tanning and libido-enhancing agent; increases melanin production and can reduce food intake and modulate sexual arousal in animal models and humans3545.

Mechanism

While GHK-Cu works as an endogenous tripeptide, Gly-His-Lys, that chelates Cu²⁺ and modulates gene expression, stimulating collagen, elastin, proteoglycan, and glycosaminoglycan synthesis while exerting antioxidant and anti-inflammatory effects31383, Melanotan II is a cyclic heptapeptide melanocortin analog (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2) that acts as a non-selective, high-potency agonist at MC1R, MC3R, MC4R, and MC5R, influencing pigmentation, appetite, and sexual behavior3545.

Length and Sequence

GHK-Cu is 3 amino acids long, whereas Melanotan II is longer as it has a length of 7 amino acids. GHK-Cu is made up of a sequence of Glycine, Histidine, Lysine. Melanotan II is made up of a sequence of Nle, Aspartic acid, Histidine, Phenylalanine, Arginine, Tryptophan, Lysine.

Receptor

GHK-Cu

Not clearly established in the current dataset.

Melanotan II

Melanocortin receptors MC1R, MC3R, MC4R, and MC5R (non-selective agonist) 3545

Organism or Origin

GHK-Cu

Naturally occurring human plasma peptide also found in saliva and urine313

Melanotan II

Synthetic analog of POMC-derived melanocortin peptides358190

Gene

GHK-Cu

Not assigned in the current dataset.

Melanotan II

POMC

Sources

3GHK-Cu: Structure And Mechanism Of Action, https://sportstechnologylabs.com/ghk-cu-structure-and-mechanism-of-action/
13What is GHK-Cu and How Does it Work?, https://www.peptidesciences.com/peptide-research/what-is-ghk-cu-and-how
83What is GHK-Cu | Peptides for sale, https://polarispeptides.com/what-is-ghk-cu/
35What is melanotan II? - Creative Peptides, https://www.creative-peptides.com/resources/what-is-melanotan-ii-peptide.html
45[PDF] melanotan-II peptide structure and molecular formula - Benchchem, https://www.benchchem.com/pdf/melanotan_II_peptide_structure_and_molecular_formula.pdf
81Proopiomelanocortin (POMC), the ACTH/melanocortin precursor, is ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC2253185/
90alpha-Melanocyte stimulating hormone: production and degradation, https://pmc.ncbi.nlm.nih.gov/articles/PMC3936413/