Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Comparison

Dulaglutide vs Selank

Also see:

DulaglutideSelank

Function

While Dulaglutide is a once-weekly GLP-1RA for type 2 diabetes that lowers HbA1c and body weight by enhancing glucose-dependent insulin secretion and reducing appetite6668, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.

Mechanism

While Dulaglutide works as a recombinant fusion protein consisting of two disulfide-linked GLP-1(7–37) analogs each covalently fused via a linker to an IgG4 Fc fragment, yielding a large, long-acting GLP-1 receptor agonist protected from DPP-4 degradation66, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.

Receptor

Dulaglutide

GLP-1 receptor (GLP1R) 6680

Selank

Not clearly established in the current dataset.

Organism or Origin

Dulaglutide

Engineered human GLP-1 analog–IgG4 Fc fusion protein produced in mammalian cell culture66

Selank

Synthetic analog of the IgG-derived tetrapeptide tuftsin39

Gene

Dulaglutide

GCG

Selank

Not assigned in the current dataset.

Summary

Dulaglutide and Selank are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Dulaglutide is more often discussed in the realm of Metabolic and endocrine, whereas Selank is more often associated with the realm of Neurology and brain health and Immunology and inflammation. They also influence different molecular systems, with Dulaglutide tracking more closely to GLP-1 receptor while Selank centers more on GPCR receptor. Dulaglutide has a more engineered peptide origin, while Selank is closer to synthetic analog background and their development context also differs, with Dulaglutide approved while Selank is approved for Research use only. Dulaglutide takes the form of a peptide conjugate, whereas Selank is closer to a linear peptide, while their sequence patterns also diverge, with Dulaglutide showing alpha-helical domain features and Selank showing proline-rich features.