Mechanism
Recombinant fusion protein consisting of two disulfide-linked GLP-1(7–37) analogs each covalently fused via a linker to an IgG4 Fc fragment, yielding a large, long-acting GLP-1 receptor agonist protected from DPP-4 degradation.66
Peptide record
Dulaglutide
Function
Once-weekly GLP-1RA for type 2 diabetes that lowers HbA1c and body weight by enhancing glucose-dependent insulin secretion and reducing appetite.6668
Receptor
Sequence
Each chain contains an N-terminal GLP-1 analog sequence (based on GLP-1(7–37)) linked to a modified human IgG4 Fc; full sequence is large and typically described structurally rather than residue-by-residue.66
Length
null amino acids
Organism or Origin
Engineered human GLP-1 analog–IgG4 Fc fusion protein produced in mammalian cell culture.66
Gene
GCG
Sources
- 66Dulaglutide | 923950-08-7 - ChemicalBook, https://amp.chemicalbook.com/ChemicalProductProperty_EN_CB12738186.htm?N=United+Kingdom
- 68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
- 80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/