Comparison

Dulaglutide vs GHRP-2

Function

While Dulaglutide is a once-weekly GLP-1RA for type 2 diabetes that lowers HbA1c and body weight by enhancing glucose-dependent insulin secretion and reducing appetite6668, GHRP-2 is used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics6272.

Mechanism

While Dulaglutide works as a recombinant fusion protein consisting of two disulfide-linked GLP-1(7–37) analogs each covalently fused via a linker to an IgG4 Fc fragment, yielding a large, long-acting GLP-1 receptor agonist protected from DPP-4 degradation66, GHRP-2 is a second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol62723096.

Length and Sequence

Dulaglutide is amino acids long, whereas GHRP-2 is longer as it has a length of 6 amino acids. Dulaglutide is made up of a sequence of sequence data not available in the current dataset. GHRP-2 is made up of a sequence of Alanine, D-2-Nal, Alanine, Tryptophan, Phenylalanine, Lysine.

Receptor

Dulaglutide

GLP-1 receptor (GLP1R) 6680

GHRP-2

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 309596104

Organism or Origin

Dulaglutide

Engineered human GLP-1 analog–IgG4 Fc fusion protein produced in mammalian cell culture66

GHRP-2

Synthetic met-enkephalin–derived hexapeptide3072

Gene

Dulaglutide

GCG

GHRP-2

GHSR

Sources

66Dulaglutide | 923950-08-7 - ChemicalBook, https://amp.chemicalbook.com/ChemicalProductProperty_EN_CB12738186.htm?N=United+Kingdom
68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/
30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
62GHRP-2: Potent Growth Hormone Releasing Peptide Guide, https://www.peptidepedia.org/performance/ghrp-2
72GHRP-2 Technical Data - Molecular Specs - Peptide Initiative, https://peptideinitiative.com/peptides/ghrp-2/technical
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor