Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While DSIP was originally described for inducing spindle and delta sleep activity when infused into the brain of rabbits; later studies report stress-modulating and endocrine effects, though its physiological role is still debated47, Selank is a peptide developed in Russia as an anxiolytic and nootropic; in animal models it reduces anxiety-like behavior and modulates immune parameters under stress39.
While DSIP works as an endogenous nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with proposed neuromodulatory actions; it interacts with components of the MAPK cascade and may be related to glucocorticoid-induced leucine zipper (GILZ), but its precise biosynthetic origin remains unknown4757, Selank is a synthetic heptapeptide, Thr-Lys-Pro-Arg-Pro-Gly-Pro, that combines a tuftsin fragment with a Pro-Gly-Pro motif and is reported to modulate GABAergic neurotransmission and cytokine balance while being resistant to proteolytic degradation39.
DSIP
Not clearly established in the current dataset.
Selank
Not clearly established in the current dataset.
DSIP
Not assigned in the current dataset.
Selank
Not assigned in the current dataset.
Both peptides fall into a similar broad context as Neuropeptides, although the details of how they are used and discussed still diverge. Both are often discussed in Neurology and brain health contexts, while DSIP is more of a neuropeptide and Selank is better described as a immune-modulating peptide. Both appear to work through Neurotransmitter modulator, but the functional emphasis still separates, with DSIP leaning toward Anxiolytic and sleep modulation and Selank leaning toward Immune regulation. DSIP has a more natural endogenous origin, while Selank is closer to synthetic analog background and both are still best understood as being approved for Research use only. They share some route overlap through subcutaneous injection, while the remaining routes diverge.
No related articles are linked to these peptides yet.