Peptable

Peptide record

DSIP

Function

DSIP is a Neuropeptide.

This Peptide was originally described for inducing spindle and delta sleep activity when infused into the brain of rabbits; later studies report stress-modulating and endocrine effects, though its physiological role is still debated47

Mechanism

DSIP is an endogenous nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with proposed neuromodulatory actions; it interacts with components of the MAPK cascade and may be related to glucocorticoid-induced leucine zipper (GILZ), but its precise biosynthetic origin remains unknown4757

DSIP is a Neurotransmitter modulator.

Receptor

Not clearly established in the current dataset.

Length

9 amino acids

Organism or Origin

Endogenous vertebrate neuropeptide; its encoding gene has not been identified47

Gene

Not assigned in the current dataset.

Sequence

N-terminusC-terminus

WAGGDASGE 4757

Tryptophan, Alanine, Glycine, Glycine, Aspartic acid, Alanine, Serine, Glycine, Glutamic acid

9 residuesapprox. 830.81 Dacharge +0 / -2 / net -2hydrophobic 3 • special 3 • acidic 2 • polar 1

Sequence-derived properties

Length

9 residues

Molecular weight

848.83 Da

Average hydrophobicity

-0.7

Unique amino acids

6

Residue class composition

hydrophobic

3 (33.3%)

special

3 (33.3%)

acidic

2 (22.2%)

polar

1 (11.1%)

Charge-category composition

neutral

7 (77.8%)

negative

2 (22.2%)

Amino acid composition

Glycine (Gly/G)

3 (33.3%)

Alanine (Ala/A)

2 (22.2%)

Aspartic acid (Asp/D)

1 (11.1%)

Glutamic acid (Glu/E)

1 (11.1%)

Serine (Ser/S)

1 (11.1%)

Tryptophan (Trp/W)

1 (11.1%)

Sources

  1. 47DSIP (Delta sleep-inducing peptide), https://particlepeptides.com/en/content/12-dsip
  2. 57Transport and metabolism of delta sleep-inducing peptide ... - PubMed, https://pubmed.ncbi.nlm.nih.gov/8689946/

Related articles

No related articles are linked to this peptide yet.