Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While CJC-1295 is used in research to chronically elevate endogenous growth hormone and IGF-1 levels, enabling studies of body composition, metabolic, and anti-aging effects of prolonged GH exposure10, GHK-Cu acts as a tissue-remodeling and wound-healing signal, enhancing skin regeneration, angiogenesis, and repair while reducing inflammation and oxidative damage in experimental models31383.
While CJC-1295 works as a tetrasubstituted 29-amino-acid analog of GHRH(1–29) that acts as a potent agonist at the GHRH receptor and, in its DAC form, covalently binds serum albumin to extend half-life from minutes to days, resulting in sustained pulsatile GH and IGF-1 increase1082, GHK-Cu is an endogenous tripeptide, Gly-His-Lys, that chelates Cu²⁺ and modulates gene expression, stimulating collagen, elastin, proteoglycan, and glycosaminoglycan synthesis while exerting antioxidant and anti-inflammatory effects31383.
CJC-1295
GHRH
GHK-Cu
Not assigned in the current dataset.
CJC-1295 and GHK-Cu are noticeably different, with limited direct overlap in their usual biological context. Both are often discussed in Aging and longevity contexts, while CJC-1295 is more of a hormone peptide and GHK-Cu is better described as a signal peptide and Matrikine. They also influence different molecular systems, with CJC-1295 tracking more closely to Growth hormone axis while GHK-Cu centers more on Extracellular matrix proteins. CJC-1295 has a more synthetic analog origin, while GHK-Cu is closer to natural endogenous background and their development context also differs, with CJC-1295 in Preclinical development while GHK-Cu is cosmetic grade. CJC-1295 incorporates d-amino acid substitution features that are not part of GHK-Cu, while their sequence patterns also diverge, with CJC-1295 showing alpha-helical domain features and GHK-Cu showing protein-mimetic sequence features.