Comparison

BPC-157 vs Kisspeptin

Function

While BPC-157 is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects111, Kisspeptin is a key regulator of the hypothalamic–pituitary–gonadal axis, controlling puberty and fertility; kisspeptin-10 also inhibits trophoblast invasion and tumor metastasis in experimental models339199.

Mechanism

While BPC-157 works as a synthetic 15-amino-acid fragment of a gastric cytoprotective protein that promotes angiogenesis and tissue protection primarily by modulating VEGFR2 signaling, Src/caveolin-1–dependent eNOS activation, and nitric oxide production111, Kisspeptin is a family of peptides (eg, kisspeptin-10, -13, -14, -54) derived from the KISS1 precursor that activate G-protein–coupled receptor KISS1R (GPR54), triggering GnRH release and regulating pubertal onset and reproductive axis activity339199.

Length and Sequence

BPC-157 is 15 amino acids long, whereas Kisspeptin is shorter as it has a length of 10 amino acids. BPC-157 is made up of a sequence of Glycine, Glutamic acid, Proline, Proline, Proline, Glycine, Lysine, Proline, Alanine, Aspartic acid, Aspartic acid, Alanine, Glycine, Leucine, Valine. Kisspeptin is made up of a sequence of Tyrosine, Asparagine, Tryptophan, Asparagine, Serine, Phenylalanine, Glycine, Leucine, Arginine, Tyrosine.

Receptor

BPC-157

VEGFR2 (vascular endothelial growth factor receptor 2) on endothelial cells, with downstream eNOS and nitric-oxide–mediated signaling11

Kisspeptin

KISS1R (GPR54) kisspeptin receptor33919943

Organism or Origin

BPC-157

Synthetic peptide derived from a naturally occurring human gastric 'Body Protection Compound' isolated from human gastric juice111

Kisspeptin

Endogenous human peptide products of the KISS1 gene9199

Gene

BPC-157

Not assigned in the current dataset.

Kisspeptin

KISS1

Sources

11BPC-157 - Wikipedia, https://en.wikipedia.org/wiki/BPC-157
70Kisspeptin-10, rat, https://pubchem.ncbi.nlm.nih.gov/compound/Kisspeptin-10_-rat
91Kisspeptin - Wikipedia, https://en.wikipedia.org/wiki/Kisspeptin
99Kisspeptin-1 - an overview, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/kisspeptin-1