Comparison

BPC-157 vs Dulaglutide

Function

While BPC-157 is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects111, Dulaglutide is a once-weekly GLP-1RA for type 2 diabetes that lowers HbA1c and body weight by enhancing glucose-dependent insulin secretion and reducing appetite6668.

Mechanism

While BPC-157 works as a synthetic 15-amino-acid fragment of a gastric cytoprotective protein that promotes angiogenesis and tissue protection primarily by modulating VEGFR2 signaling, Src/caveolin-1–dependent eNOS activation, and nitric oxide production111, Dulaglutide is a recombinant fusion protein consisting of two disulfide-linked GLP-1(7–37) analogs each covalently fused via a linker to an IgG4 Fc fragment, yielding a large, long-acting GLP-1 receptor agonist protected from DPP-4 degradation66.

Length and Sequence

BPC-157 is 15 amino acids long, whereas Dulaglutide is shorter as it has a length of amino acids. BPC-157 is made up of a sequence of Glycine, Glutamic acid, Proline, Proline, Proline, Glycine, Lysine, Proline, Alanine, Aspartic acid, Aspartic acid, Alanine, Glycine, Leucine, Valine. Dulaglutide is made up of a sequence of sequence data not available in the current dataset.

Receptor

BPC-157

VEGFR2 (vascular endothelial growth factor receptor 2) on endothelial cells, with downstream eNOS and nitric-oxide–mediated signaling11

Dulaglutide

GLP-1 receptor (GLP1R) 6680

Organism or Origin

BPC-157

Synthetic peptide derived from a naturally occurring human gastric 'Body Protection Compound' isolated from human gastric juice111

Dulaglutide

Engineered human GLP-1 analog–IgG4 Fc fusion protein produced in mammalian cell culture66

Gene

BPC-157

Not assigned in the current dataset.

Dulaglutide

GCG

Sources

11BPC-157 - Wikipedia, https://en.wikipedia.org/wiki/BPC-157
66Dulaglutide | 923950-08-7 - ChemicalBook, https://amp.chemicalbook.com/ChemicalProductProperty_EN_CB12738186.htm?N=United+Kingdom
68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/