Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While AOD-9604 is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115, LL-37 acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215.
While AOD-9604 works as a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111, LL-37 is a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586.
AOD-9604
LL-37
AOD-9604
GH1
LL-37
CAMP
AOD-9604 and LL-37 are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: AOD-9604 is more often discussed in the realm of Metabolic and endocrine, whereas LL-37 is more often associated with the realm of Immunology and inflammation and Gastroenterology. Their biological logic is quite different: AOD-9604 is a hormone analog, whereas LL-37 is a membrane disruptor and a signaling modulator. AOD-9604 has a more synthetic analog origin, while LL-37 is closer to natural endogenous background and both are still best understood as being in Preclinical development. Their sequence patterns also diverge, with AOD-9604 showing hydrophobic domain features and LL-37 showing cationic amphipathic and alpha-helical domain features.
No related articles are linked to these peptides yet.