Comparison
While AOD-9604 is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115, Humanin exerts neuroprotective and cytoprotective effects in models of Alzheimer’s disease, ischemia, and metabolic stress, reducing apoptosis and improving cell survival7136141.
While AOD-9604 works as a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111, Humanin is a mitochondrial-derived 24-amino-acid peptide that protects cells against diverse apoptotic insults by interacting with cell-surface cytokine receptor complexes and intracellular targets, thereby activating pro-survival STAT3 and other pathways7136141.
AOD-9604 is 16 amino acids long, whereas Humanin is longer as it has a length of 24 amino acids. AOD-9604 is made up of a sequence of Tyrosine, Leucine, Arginine, Isoleucine, Valine, Glutamine, Cysteine, Arginine, Serine, Valine, Glutamic acid, Glycine, Serine, Cysteine, Glycine, Phenylalanine. Humanin is made up of a sequence of Methionine, Alanine, Proline, Arginine, Glycine, Phenylalanine, Serine, Cysteine, Leucine, Leucine, Leucine, Leucine, Leucine, Threonine, Serine, Glutamic acid, Isoleucine, Aspartic acid, Leucine, Proline, Valine, Lysine, Arginine, Arginine, Alanine.
AOD-9604
Humanin
AOD-9604
GH1
Humanin
MT-RNR2
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