Function
While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Thymosin Beta-4 promotes wound healing, angiogenesis, and tissue regeneration in preclinical models via effects on cytoskeleton dynamics, cell migration, and anti-apoptotic pathways25579.
Mechanism
While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Thymosin Beta-4 is an endogenous 43-amino-acid actin-sequestering peptide that maintains a pool of G-actin monomers and regulates actin polymerization, thereby influencing cell migration, proliferation, and differentiation25579.
Length and Sequence
Acetyl tetrapeptide-5 is 4 amino acids long, whereas Thymosin Beta-4 is longer as it has a length of 43 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. Thymosin Beta-4 is made up of a sequence of Serine, Aspartic acid, Lysine, Proline, Aspartic acid, Methionine, Alanine, Glutamic acid, Isoleucine, Glutamic acid, Lysine, Phenylalanine, Aspartic acid, Lysine, Serine, Lysine, Lysine, Proline, Aspartic acid, Methionine, Alanine, Glutamic acid, Glutamic acid, Lysine, Phenylalanine, Aspartic acid, Lysine, Lysine, Glutamic acid, Lysine, Lysine, Glutamic acid, Glutamic acid, Alanine, Glutamic acid, Asparagine, Glutamic acid, Glutamic acid, Lysine, Glutamic acid, Serine.