Comparison

Acetyl tetrapeptide-5 vs SS-31

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas SS-31 is the same length as it has a length of 4 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

SS-31

Cardiolipin-rich inner mitochondrial membrane; interacts with cardiolipin and associated mitochondrial proteins rather than a classical cell-surface receptor46137143

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

SS-31

Fully synthetic Szeto–Schiller tetrapeptide; not encoded in the genome4637

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

SS-31

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
46Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2 ... - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC11409442/
56Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2 ..., https://pubs.rsc.org/en/content/articlelanding/2024/ra/d4ra05517a
137Mitochondrial protein interaction landscape of SS-31 | PNAS, https://www.pnas.org/doi/10.1073/pnas.2002250117
143SS-31 Peptide: Mitochondrial Repair for Energy and Longevity, https://revolutionhealth.org/blogs/news/peptide-therapy-ss-31