Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Acetyl tetrapeptide-5
SS-31
Acetyl tetrapeptide-5
Not assigned in the current dataset.
SS-31
Not assigned in the current dataset.
The clearest overlap between Acetyl tetrapeptide-5 and SS-31 is that both converge around Signaling modulator. Their typical research and application settings separate fairly clearly: Acetyl tetrapeptide-5 is more often discussed in the realm of Dermatology and aesthetics, whereas SS-31 is more often associated with the realm of Aging and longevity and Cardiovascular health. Both appear to work through Signaling modulator, but the functional emphasis still separates, with Acetyl tetrapeptide-5 leaning toward Anti-inflammatory and SS-31 leaning toward Mitochondrial function modulation, Antioxidant activity, and Neuroprotection and cognition. Both are synthetic in origin and their development context also differs, with Acetyl tetrapeptide-5 cosmetic grade while SS-31 is in Clinical phase 2. Acetyl tetrapeptide-5 carries acetylation features, while SS-31 instead reflects d-amino acid substitution and amidation changes.
No related articles are linked to these peptides yet.