Comparison

Acetyl tetrapeptide-5 vs MGF

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, MGF is upregulated in muscle after mechanical overload, where it supports tissue repair and growth; recombinant forms are studied for regenerative and performance-enhancement effects22138.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, MGF is a 24-amino-acid E-peptide splice variant of IGF-1 (IGF-1Ec) produced in mechanically stressed or damaged muscle that activates IGF1R and local anabolic pathways involved in muscle repair and hypertrophy22138144.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas MGF is longer as it has a length of 24 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. MGF is made up of a sequence of Tyrosine, Glutamine, Proline, Proline, Serine, Threonine, Asparagine, Lysine, Asparagine, Threonine, Lysine, Serine, Glutamine, Arginine, Arginine, Lysine, Glycine, Serine, Threonine, Phenylalanine, Glutamic acid, Glutamic acid, Arginine, Lysine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

MGF

Insulin-like growth factor 1 receptor (IGF1R) 134139

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

MGF

Endogenous human IGF-1 splice variant (IGF-1Ec) 2213897

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

MGF

IGF1

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
22Mechano growth factor - Wikipedia, https://en.wikipedia.org/wiki/Mechano_growth_factor
97IGF1 Gene - Insulin Like Growth Factor 1, https://www.genecards.org/cgi-bin/carddisp.pl?gene=IGF1
134Insulin-like growth factor 1 receptor - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1_receptor
138A Splice Variant of IGF-1 within the Growth Plate | PLOS One, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076133
139IGF1 receptor signaling pathways, https://pubmed.ncbi.nlm.nih.gov/29535161/
144Insulin-like growth factor 1 - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1