Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.
While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.
Acetyl tetrapeptide-5
Not assigned in the current dataset.
Matrixyl
Not assigned in the current dataset.
Both peptides fall into a similar broad context as Signal peptides, although the details of how they are used and discussed still diverge. Both are often discussed in Dermatology and aesthetics contexts, while Acetyl tetrapeptide-5 is more of a signal peptide and Matrixyl is better described as a matrikine. Their biological logic is quite different: Acetyl tetrapeptide-5 is a signaling modulator, whereas Matrixyl is a matrix remodeling modulator. Both are synthetic in origin. Acetyl tetrapeptide-5 takes the form of a linear peptide, whereas Matrixyl is closer to a peptide conjugate, while Acetyl tetrapeptide-5 carries acetylation features, while Matrixyl instead reflects palmitoylation changes.
No related articles are linked to these peptides yet.