Comparison

Acetyl tetrapeptide-5 vs Matrixyl

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas Matrixyl is longer as it has a length of 5 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. Matrixyl is made up of a sequence of Lysine, Threonine, Threonine, Lysine, Serine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

Matrixyl

Not clearly established in the current dataset.

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

Matrixyl

Synthetic lipopeptide derived from a collagen I C-terminal fragment sequence5158

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

Matrixyl

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
48Palmitoyl Pentapeptide-4 - R&D PEPTIDE.ONE, https://rnd.peptide.one/product/palmitoyl-pentapeptide-4-pal-lys-thr-thr-lys-ser/
51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
58[PDF] Safety Assessment of Myristoyl Pentapeptide-4, Palmitoyl ..., https://www.cir-safety.org/sites/default/files/Pentapeptide%20Ingredients.pdf