Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36.
While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36.
Acetyl tetrapeptide-5
Not assigned in the current dataset.
Epitalon
Not assigned in the current dataset.
Both peptides fall into a similar broad context as Signal peptides, although the details of how they are used and discussed still diverge. Their typical research and application settings separate fairly clearly: Acetyl tetrapeptide-5 is more often discussed in the realm of Dermatology and aesthetics, whereas Epitalon is more often associated with the realm of Aging and longevity. Both appear to work through Signaling modulator, but the functional emphasis still separates, with Acetyl tetrapeptide-5 leaning toward Anti-inflammatory and Epitalon leaning toward Mitochondrial function modulation and Antioxidant activity. Acetyl tetrapeptide-5 has a more synthetic design origin, while Epitalon is closer to synthetic analog background and their development context also differs, with Acetyl tetrapeptide-5 cosmetic grade while Epitalon is approved for Research use only. Acetyl tetrapeptide-5 incorporates acetylation features that are not part of Epitalon.
No related articles are linked to these peptides yet.