Comparison

Acetyl tetrapeptide-5 vs Epitalon

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Epitalon is reported to increase lifespan and reduce tumor incidence in animals, and to influence differentiation of neural and mesenchymal stem cells; is studied as an epigenetic regulatory peptide36.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Epitalon is a synthetic tetrapeptide, Ala-Glu-Asp-Gly (AEDG), that has been shown to bind histones and modulate gene expression and chromatin state, with reported effects on pineal function, neurogenesis, and longevity in animal models36.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas Epitalon is the same length as it has a length of 4 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. Epitalon is made up of a sequence of Alanine, Glutamic acid, Aspartic acid, Glycine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

Epitalon

Binds nuclear histone proteins (H1, H2B, H3, H4) rather than a classic membrane receptor36

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

Epitalon

Synthetic peptide modeled after a pineal gland peptide fraction; not directly encoded as a standalone peptide in humans36

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

Epitalon

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
36AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC7037223/