Comparison
While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, DSIP was originally described for inducing spindle and delta sleep activity when infused into the brain of rabbits; later studies report stress-modulating and endocrine effects, though its physiological role is still debated47.
While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, DSIP is an endogenous nonapeptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, with proposed neuromodulatory actions; it interacts with components of the MAPK cascade and may be related to glucocorticoid-induced leucine zipper (GILZ), but its precise biosynthetic origin remains unknown4757.
Acetyl tetrapeptide-5 is 4 amino acids long, whereas DSIP is longer as it has a length of 9 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. DSIP is made up of a sequence of Tryptophan, Alanine, Glycine, Glycine, Aspartic acid, Alanine, Serine, Glycine, Glutamic acid.
Acetyl tetrapeptide-5
Not assigned in the current dataset.
DSIP
Not assigned in the current dataset.
No related articles are linked to these peptides yet.