Function

Tirzepatide is a Metabolic peptide.

This Peptide is approved for type 2 diabetes and obesity, producing larger HbA1c and body-weight reductions than semaglutide in head-to-head trials24

Mechanism

Tirzepatide is a 39-amino-acid synthetic peptide primarily based on GIP sequence with C20 fatty diacid conjugation that acts as a dual agonist at GIP and GLP-1 receptors, enhancing glucose-dependent insulin secretion, suppressing glucagon, delaying gastric emptying, and reducing appetite24

Tirzepatide is a Receptor agonist.

Receptor

Glucose-dependent insulinotropic polypeptide receptor (GIPR) and GLP-1 receptor (GLP1R) 24

Sequence note

39-amino-acid GIP-based backbone with multiple substitutions and a C20 fatty diacid side chain; exact residue-level sequence is proprietary but characterized as a 39-aa dual incretin analog 24

Length

39 amino acids

Organism or Origin

Synthetic dual GIP/GLP-1 receptor agonist modeled on human incretin hormones2480

Gene

Not assigned in the current dataset.