Peptide record
Modified GLP-1(7–37) analog with three key changes—Ala8→Aib, Lys26 acylated with a C18 fatty diacid, and Lys34→Arg—resulting in a long-acting GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite.23647480
Approved for type 2 diabetes and chronic weight management, significantly lowering HbA1c and body weight by modulating incretin pathways.232480
GLP-1 receptor (GLP1R) on pancreatic β-cells and other tissues.2380
31-amino-acid backbone based on human GLP-1(7–37) with Aib8, Arg34, and a C18 fatty acid chain attached to Lys26; overall modified GLP-1 sequence.236474
31 amino acids
Synthetic analog of human GLP-1 derived from proglucagon.648089
GCG