Function

Semaglutide is a Metabolic peptide.

This Peptide is approved for type 2 diabetes and chronic weight management, significantly lowering HbA1c and body weight by modulating incretin pathways232480

Mechanism

Semaglutide is a modified GLP-1(7–37) analog with three key changes—Ala8→Aib, Lys26 acylated with a C18 fatty diacid, and Lys34→Arg—resulting in a long-acting GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite23647480

Semaglutide is a Receptor agonist.

Receptor

GLP-1 receptor (GLP1R) on pancreatic β-cells and other tissues2380

Sequence note

31-amino-acid backbone based on human GLP-1(7–37) with Aib8, Arg34, and a C18 fatty acid chain attached to Lys26; overall modified GLP-1 sequence 236474

Length

31 amino acids

Organism or Origin

Synthetic analog of human GLP-1 derived from proglucagon648089

Gene

GCG