Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

Semaglutide

Function

Semaglutide is a Metabolic peptide.

This Peptide is approved for type 2 diabetes and chronic weight management, significantly lowering HbA1c and body weight by modulating incretin pathways232480

Mechanism

Semaglutide is a modified GLP-1(7–37) analog with three key changes—Ala8→Aib, Lys26 acylated with a C18 fatty diacid, and Lys34→Arg—resulting in a long-acting GLP-1 receptor agonist that enhances glucose-dependent insulin secretion, suppresses glucagon, slows gastric emptying, and reduces appetite23647480

Semaglutide is a Receptor agonist.

Receptor

GLP-1 receptor (GLP1R) on pancreatic β-cells and other tissues2380

Sequence note

31-amino-acid backbone based on human GLP-1(7–37) with Aib8, Arg34, and a C18 fatty acid chain attached to Lys26; overall modified GLP-1 sequence 236474

Length

31 amino acids

Organism or Origin

Synthetic analog of human GLP-1 derived from proglucagon648089

Gene

GCG

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 23Semaglutide (GLP-1 Receptor Agonist) — Mechanism, Research ..., https://orynxpeptides.com/de/peptides/encyclopedia/semaglutide
  2. 24Tirzepatide - a dual GIP and GLP-1 (GLP1) receptor agonist, https://gpnotebook.com/pages/diabetes-and-endocrinology/tirzepatide-a-dual-gip-and-glp-1-glp1-receptor-agonist
  3. 64Semaglutide Structure & Chemistry: Molecular Details | The ..., https://www.thejops.com/peptides/semaglutide/chemistry.html
  4. 74Drug Interactions And Side..., https://pdb101.rcsb.org/global-health/diabetes-mellitus/drugs/incretins/drug/semaglutide/semaglutide
  5. 80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/
  6. 89Gene, https://maayanlab.cloud/Harmonizome/gene/GCG

Related articles

GLP-1 Receptor Agonists (Semaglutide Focus)Semaglutide

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Compiled from published literature and reference databases. See the editorial policy.

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