Peptable

Acetyl tetrapeptide-5

is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation

Peptide

Alanine

Ala / A · hydrophobic residue · neutral charge

Amino acid

AOD-9604

is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials

Peptide

Arginine

Arg / R · basic residue · positive charge

Amino acid

Argireline

is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner

Peptide

Asparagine

Asn / N · polar residue · neutral charge

Amino acid

Aspartic acid

Asp / D · acidic residue · negative charge

Amino acid

BPC-157

is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects

Peptide

Peptide record

PEG-MGF

Function

PEG-MGF is a Signal peptide.

This Peptide is used experimentally to enhance muscle repair and hypertrophy after mechanical overload or injury by stimulating satellite-cell activation and protein synthesis6373138

Mechanism

PEG-MGF is a poly(ethylene glycol)-conjugated form of Mechano Growth Factor (IGF-1Ec splice variant) comprising the 24-aa C-terminal E-peptide of IGF-1, designed to extend half-life while activating IGF-1 receptor–mediated anabolic signaling in muscle satellite cells637322138

PEG-MGF is a Growth factor mimetic.

Receptor

Insulin-like growth factor 1 receptor (IGF1R), the canonical receptor for IGF-1 peptides22133134139

Length

24 amino acids

Organism or Origin

Synthetic PEGylated analog of human MGF (IGF-1Ec isoform) 2273138

Gene

IGF1

Sequence

PEGN-terminus
Tyr
Gln
Pro
Pro
Ser
Thr
Asn
Lys
Asn
Thr
Lys
Ser
Gln
Arg
Arg
Lys
Gly
Ser
Thr
Phe
Glu
Glu
Arg
Lys
C-terminus

PEG-YQPPSTNKNTKSQRRKGSTFEERK 6373

Tyrosine, Glutamine, Proline, Proline, Serine, Threonine, Asparagine, Lysine, Asparagine, Threonine, Lysine, Serine, Glutamine, Arginine, Arginine, Lysine, Glycine, Serine, Threonine, Phenylalanine, Glutamic acid, Glutamic acid, Arginine, Lysine

24 residuesapprox. 2850.17 Dacharge +7 / -2 / net +5polar 11 • special 3 • basic 7 • hydrophobic 1 • acidic 2

Sequence-derived properties

Sequence-derived properties are omitted because the stored sequence includes non-residue terminal modifiers.

Sources

  1. 22Mechano growth factor - Wikipedia, https://en.wikipedia.org/wiki/Mechano_growth_factor
  2. 63Sourcing, https://exploring-peptides.com/peptide-wikipedia/pegmgf/
  3. 73PEG-MGF, https://peptidestandard.com/peg-mgf-research/
  4. 133IGF1R - Abcam, https://www.abcam.com/en-us/targets/igf1r/24611
  5. 134Insulin-like growth factor 1 receptor - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1_receptor
  6. 138A Splice Variant of IGF-1 within the Growth Plate | PLOS One, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076133
  7. 139IGF1 receptor signaling pathways, https://pubmed.ncbi.nlm.nih.gov/29535161/

Related articles

No related articles are linked to this peptide yet.