Peptide record

PEG-MGF

Mechanism

Poly(ethylene glycol)-conjugated form of Mechano Growth Factor (IGF-1Ec splice variant) comprising the 24-aa C-terminal E-peptide of IGF-1, designed to extend half-life while activating IGF-1 receptor–mediated anabolic signaling in muscle satellite cells.63 73 22 138

Function

Used experimentally to enhance muscle repair and hypertrophy after mechanical overload or injury by stimulating satellite-cell activation and protein synthesis.63 73 138

Receptor

Insulin-like growth factor 1 receptor (IGF1R), the canonical receptor for IGF-1 peptides.22 133 134 139

Sequence

PEG-Tyr-Gln-Pro-Pro-Ser-Thr-Asn-Lys-Asn-Thr-Lys-Ser-Gln-Arg-Arg-Lys-Gly-Ser-Thr-Phe-Glu-Glu-Arg-Lys63 73

Length

24 amino acids

Organism or Origin

Synthetic PEGylated analog of human MGF (IGF-1Ec isoform). 22 73 138

Gene

IGF1

Sources

22Mechano growth factor - Wikipedia, https://en.wikipedia.org/wiki/Mechano_growth_factor
63Sourcing, https://exploring-peptides.com/peptide-wikipedia/pegmgf/
73PEG-MGF, https://peptidestandard.com/peg-mgf-research/
133IGF1R - Abcam, https://www.abcam.com/en-us/targets/igf1r/24611
134Insulin-like growth factor 1 receptor - Wikipedia, https://en.wikipedia.org/wiki/Insulin-like_growth_factor_1_receptor
138A Splice Variant of IGF-1 within the Growth Plate | PLOS One, https://journals.plos.org/plosone/article?id=10.1371%2Fjournal.pone.0076133
139IGF1 receptor signaling pathways, https://pubmed.ncbi.nlm.nih.gov/29535161/

No related articles are linked to this peptide yet.