Peptable

Peptide record

Liraglutide

Function

Liraglutide is a Metabolic peptide.

This Peptide is approved for type 2 diabetes and weight management, improving glycemic control and inducing weight loss through GLP-1–mediated insulinotropic, glucagonostatic, and appetite-suppressing actions6880

Mechanism

Liraglutide is a human GLP-1 analog with a single amino-acid substitution (Lys34→Arg) and a C16 palmitoyl fatty acid attached to Lys26 via a glutamate linker, producing a long-acting GLP-1 receptor agonist6880

Liraglutide is a Receptor agonist.

Receptor

GLP-1 receptor (GLP1R) 6880

Sequence note

GLP-1(7–37) analog with 97% sequence homology to native GLP-1, incorporating Lys34Arg and a C16 acyl chain on Lys26; 31 amino acids 68

Length

31 amino acids

Organism or Origin

Synthetic analog of human GLP-16880

Gene

GCG

Sequence-derived properties

Sequence data is not available in the current dataset.

Sources

  1. 68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
  2. 80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/

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