Peptide record

Liraglutide

Mechanism

Human GLP-1 analog with a single amino-acid substitution (Lys34→Arg) and a C16 palmitoyl fatty acid attached to Lys26 via a glutamate linker, producing a long-acting GLP-1 receptor agonist.68 80

Function

Approved for type 2 diabetes and weight management, improving glycemic control and inducing weight loss through GLP-1–mediated insulinotropic, glucagonostatic, and appetite-suppressing actions.68 80

Receptor

GLP-1 receptor (GLP1R). 68 80

Sequence

GLP-1(7–37) analog with 97% sequence homology to native GLP-1, incorporating Lys34Arg and a C16 acyl chain on Lys26; 31 amino acids.68

Length

31 amino acids

Organism or Origin

Synthetic analog of human GLP-1.68 80

Gene

GCG

Sources

68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/

GLP-1 Receptor Agonists (Semaglutide Focus)