Function

FOXO4-DRI is a Senolytic peptide.

This Peptide acts as a senolytic in preclinical models by promoting apoptosis of senescent cells, improving tissue function and healthspan measures in aged animals38

Mechanism

FOXO4-DRI is a D-retro-inverso peptide derived from a FOXO4 region that competes with endogenous FOXO4 for binding to p53, thereby releasing p53 to trigger apoptosis selectively in senescent cells38

FOXO4-DRI is a Protein interaction inhibitor.

Receptor

Intracellular target is the FOXO4–p53 protein–protein interaction interface; it does not signal via a traditional cell-surface receptor38

Sequence note

D-retro-inverso version of a FOXO4 peptide segment (exact D-amino-acid sequence defined in the original Erasmus Medical Center work) 38

Length

null amino acids

Organism or Origin

Synthetic peptide based on human FOXO4 transcription factor3898

Gene

FOXO4