Peptide record

FOXO4-DRI

Mechanism

D-retro-inverso peptide derived from a FOXO4 region that competes with endogenous FOXO4 for binding to p53, thereby releasing p53 to trigger apoptosis selectively in senescent cells.38

Function

Acts as a senolytic in preclinical models by promoting apoptosis of senescent cells, improving tissue function and healthspan measures in aged animals.38

Receptor

Intracellular target is the FOXO4–p53 protein–protein interaction interface; it does not signal via a traditional cell-surface receptor.38

Sequence

D-retro-inverso version of a FOXO4 peptide segment (exact D-amino-acid sequence defined in the original Erasmus Medical Center work). 38

Length

null amino acids

Organism or Origin

Synthetic peptide based on human FOXO4 transcription factor.38 98

Gene

FOXO4

Sources

38FOXO4-DRI - Research Information - Peptpedia, https://peptpedia.org/peptide/foxo4-dri
98Human FOXO4 Synthetic Peptide (PEP-1088), https://www.thermofisher.com/proteins/product/Human-FOXO4-Synthetic-Peptide/PEP-1088

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