Mechanism
39-amino-acid exendin-4 peptide originally isolated from Gila monster venom that acts as a long-acting GLP-1 receptor agonist resistant to DPP-4 degradation.67
Peptide record
Exenatide
Function
Used for type 2 diabetes treatment to improve glycemic control and modestly reduce body weight through GLP-1–like insulinotropic and glucagonostatic effects.6768
Receptor
Sequence
Exendin-4 is a 39-amino-acid peptide incretin mimetic; the full sequence is well characterized but often referenced simply as exendin-4 (39 aa GLP-1R agonist). 67
Length
39 amino acids
Organism or Origin
Originally from Heloderma suspectum (Gila monster) venom; now produced synthetically.67
Gene
Not assigned in the current dataset.
Sources
- 67Exendin 4 – Potent GLP-1R agonist - SB PEPTIDE, https://www.sb-peptide.com/project/exendin-4-potent-glp-1r-agonist/
- 68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
- 80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/