Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929, MOTS-c improves insulin sensitivity, enhances glycolysis, reduces oxidative stress, and shows protective effects in models of metabolic syndrome, aging, and ischemia-reperfusion injury8135146.
While Hexarelin works as a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996, MOTS-c is a 16-amino-acid mitochondrial-derived peptide that translocates to the nucleus under metabolic stress and regulates glucose and lipid metabolism largely via activation of AMPK and modulation of mTOR and folate-cycle–linked pathways854140146.
Hexarelin
GHSR
MOTS-c
MT-RNR1
Hexarelin and MOTS-c are noticeably different, with limited direct overlap in their usual biological context. Both are often discussed in Metabolic and endocrine contexts, while Hexarelin is more of a hormone peptide and MOTS-c is better described as a mitochondrial peptide and Metabolic peptide. They also influence different molecular systems, with Hexarelin tracking more closely to Ghrelin receptor while MOTS-c centers more on Mitochondrial membrane. Hexarelin has a more synthetic design origin, while MOTS-c is closer to mitochondrial-encoded background and both are still best understood as being in Preclinical development. Hexarelin incorporates d-amino acid substitution and amidation features that are not part of MOTS-c, while their sequence patterns also diverge, with Hexarelin showing protein-mimetic sequence features and MOTS-c showing hydrophobic domain features.
No related articles are linked to these peptides yet.