Comparison

Hexarelin vs Matrixyl

Function

While Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.

Mechanism

While Hexarelin works as a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.

Length and Sequence

Hexarelin is 6 amino acids long, whereas Matrixyl is shorter as it has a length of 5 amino acids. Hexarelin is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine. Matrixyl is made up of a sequence of Lysine, Threonine, Threonine, Lysine, Serine.

Receptor

Hexarelin

Primary: GHSR-1a (ghrelin receptor); also binds the scavenger receptor CD36 in vascular and macrophage tissues192129

Matrixyl

Not clearly established in the current dataset.

Organism or Origin

Hexarelin

Fully synthetic growth hormone secretagogue29

Matrixyl

Synthetic lipopeptide derived from a collagen I C-terminal fragment sequence5158

Gene

Hexarelin

GHSR

Matrixyl

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

19Identification of the growth hormone-releasing peptide binding site ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC1133797/
21Hexarelin Peptide | Strength & Recovery - Paragon Sports Medicine, https://www.paragonsportsmedicine.com/peptides/hexarelin
29Examorelin - Wikipedia, https://en.wikipedia.org/wiki/Examorelin
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
48Palmitoyl Pentapeptide-4 - R&D PEPTIDE.ONE, https://rnd.peptide.one/product/palmitoyl-pentapeptide-4-pal-lys-thr-thr-lys-ser/
51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
58[PDF] Safety Assessment of Myristoyl Pentapeptide-4, Palmitoyl ..., https://www.cir-safety.org/sites/default/files/Pentapeptide%20Ingredients.pdf