Comparison

Hexarelin vs LL-37

Function

While Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929, LL-37 acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215.

Mechanism

While Hexarelin works as a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996, LL-37 is a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586.

Length and Sequence

Hexarelin is 6 amino acids long, whereas LL-37 is longer as it has a length of 37 amino acids. Hexarelin is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine. LL-37 is made up of a sequence of Leucine, Leucine, Glycine, Aspartic acid, Phenylalanine, Phenylalanine, Arginine, Lysine, Serine, Lysine, Glutamic acid, Lysine, Isoleucine, Glycine, Lysine, Glutamic acid, Phenylalanine, Lysine, Arginine, Isoleucine, Valine, Glutamine, Arginine, Isoleucine, Lysine, Aspartic acid, Phenylalanine, Leucine, Arginine, Asparagine, Leucine, Valine, Proline, Arginine, Threonine, Glutamic acid, Serine.

Receptor

Hexarelin

Primary: GHSR-1a (ghrelin receptor); also binds the scavenger receptor CD36 in vascular and macrophage tissues192129

LL-37

Functions as a ligand for CXCR2 on neutrophils and other myeloid cells; LL-37 signaling has also been linked to FPR2 and P2X7 in various cell types515

Organism or Origin

Hexarelin

Fully synthetic growth hormone secretagogue29

LL-37

Human cathelicidin antimicrobial peptide generated from the CAP-18 precursor5286

Gene

Hexarelin

GHSR

LL-37

CAMP

Related articles

No related articles are linked to these peptides yet.

Sources

19Identification of the growth hormone-releasing peptide binding site ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC1133797/
21Hexarelin Peptide | Strength & Recovery - Paragon Sports Medicine, https://www.paragonsportsmedicine.com/peptides/hexarelin
29Examorelin - Wikipedia, https://en.wikipedia.org/wiki/Examorelin
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
52Cathelicidin LL-37: A new important molecule in the ... - PMC - NIH, https://pmc.ncbi.nlm.nih.gov/articles/PMC7388365/
86Cathelicidin antimicrobial peptide - Wikipedia, https://en.wikipedia.org/wiki/Cathelicidin_antimicrobial_peptide