Comparison

GHRP-2 vs Hexarelin

Function

While GHRP-2 is used in research to induce robust GH pulses and study anabolic and metabolic effects; clinically developed as pralmorelin for GH deficiency diagnostics6272, Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929.

Mechanism

While GHRP-2 works as a second-generation hexapeptide growth hormone–releasing peptide that mimics ghrelin by agonizing GHSR-1a, strongly stimulating pulsatile GH release and modestly raising prolactin, ACTH, and cortisol62723096, Hexarelin is a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996.

Length and Sequence

GHRP-2 is 6 amino acids long, whereas Hexarelin is the same length as it has a length of 6 amino acids. GHRP-2 is made up of a sequence of Alanine, D-2-Nal, Alanine, Tryptophan, Phenylalanine, Lysine. Hexarelin is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine.

Receptor

GHRP-2

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 309596104

Hexarelin

Primary: GHSR-1a (ghrelin receptor); also binds the scavenger receptor CD36 in vascular and macrophage tissues192129

Organism or Origin

GHRP-2

Synthetic met-enkephalin–derived hexapeptide3072

Hexarelin

Fully synthetic growth hormone secretagogue29

Gene

GHRP-2

GHSR

Hexarelin

GHSR

Related articles

No related articles are linked to these peptides yet.

Sources

30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
62GHRP-2: Potent Growth Hormone Releasing Peptide Guide, https://www.peptidepedia.org/performance/ghrp-2
72GHRP-2 Technical Data - Molecular Specs - Peptide Initiative, https://peptideinitiative.com/peptides/ghrp-2/technical
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor
19Identification of the growth hormone-releasing peptide binding site ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC1133797/
21Hexarelin Peptide | Strength & Recovery - Paragon Sports Medicine, https://www.paragonsportsmedicine.com/peptides/hexarelin
29Examorelin - Wikipedia, https://en.wikipedia.org/wiki/Examorelin
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor