Comparison

Dulaglutide vs Hexarelin

Function

While Dulaglutide is a once-weekly GLP-1RA for type 2 diabetes that lowers HbA1c and body weight by enhancing glucose-dependent insulin secretion and reducing appetite6668, Hexarelin is investigated for effects on GH secretion, cardiac protection, and muscle metabolism, with higher GH secretory potency than earlier GHRPs1929.

Mechanism

While Dulaglutide works as a recombinant fusion protein consisting of two disulfide-linked GLP-1(7–37) analogs each covalently fused via a linker to an IgG4 Fc fragment, yielding a large, long-acting GLP-1 receptor agonist protected from DPP-4 degradation66, Hexarelin is a potent synthetic hexapeptide (examorelin) that agonizes GHSR-1a to stimulate GH release and also binds CD36, influencing cardiovascular and metabolic pathways19212996.

Length and Sequence

Dulaglutide is amino acids long, whereas Hexarelin is longer as it has a length of 6 amino acids. Dulaglutide is made up of a sequence of sequence data not available in the current dataset. Hexarelin is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine.

Receptor

Dulaglutide

GLP-1 receptor (GLP1R) 6680

Hexarelin

Primary: GHSR-1a (ghrelin receptor); also binds the scavenger receptor CD36 in vascular and macrophage tissues192129

Organism or Origin

Dulaglutide

Engineered human GLP-1 analog–IgG4 Fc fusion protein produced in mammalian cell culture66

Hexarelin

Fully synthetic growth hormone secretagogue29

Gene

Dulaglutide

GCG

Hexarelin

GHSR

Sources

66Dulaglutide | 923950-08-7 - ChemicalBook, https://amp.chemicalbook.com/ChemicalProductProperty_EN_CB12738186.htm?N=United+Kingdom
68Glucagon-like peptide-1 analogues: An overview - PMC, https://pmc.ncbi.nlm.nih.gov/articles/PMC3712370/
80GLP-1 Localisation and Proglucagon Gene Expression in ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC6200298/
19Identification of the growth hormone-releasing peptide binding site ..., https://pmc.ncbi.nlm.nih.gov/articles/PMC1133797/
21Hexarelin Peptide | Strength & Recovery - Paragon Sports Medicine, https://www.paragonsportsmedicine.com/peptides/hexarelin
29Examorelin - Wikipedia, https://en.wikipedia.org/wiki/Examorelin
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor