Comparison
While Argireline is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner49, SS-31 improves mitochondrial bioenergetics, reduces oxidative stress, and shows protective effects in models of ischemia-reperfusion, neurodegeneration, and other mitochondrial disorders4637137.
While Argireline works as acetyl hexapeptide-8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2), a SNAP-25–mimetic peptide that competitively inhibits SNARE complex assembly, reducing acetylcholine release at neuromuscular junctions and attenuating facial muscle contraction4959, SS-31 is a mitochondria-targeted tetrapeptide, d-Arg-dimethylTyr-Lys-Phe-NH2, that selectively binds cardiolipin in the inner mitochondrial membrane, stabilizing cristae structure, improving electron transport, and reducing ROS production4637137143.
Argireline is 6 amino acids long, whereas SS-31 is shorter as it has a length of 4 amino acids. Argireline is made up of a sequence of Glutamic acid, Glutamic acid, Methionine, Glutamine, Arginine, Arginine. SS-31 is made up of a sequence of Arginine, dimethylTyr, Lysine, Phenylalanine.
Argireline
Molecular target is the SNARE complex component SNAP-25 rather than a classical receptor; it interferes with SNAP-25 participation in vesicle fusion49
SS-31
Argireline
Not assigned in the current dataset.
SS-31
Not assigned in the current dataset.
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