Comparison
While Argireline is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner49, PT-141 is FDA-approved for treatment of hypoactive sexual desire disorder in premenopausal women and is studied for sexual dysfunction in other populations, increasing sexual desire via CNS melanocortin pathways42101.
While Argireline works as acetyl hexapeptide-8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2), a SNAP-25–mimetic peptide that competitively inhibits SNARE complex assembly, reducing acetylcholine release at neuromuscular junctions and attenuating facial muscle contraction4959, PT-141 is the synthetic melanocortin receptor agonist bremelanotide, an analog of α-MSH that activates central MC3R and MC4R to modulate neuronal circuits governing sexual desire and arousal3242101.
Argireline is 6 amino acids long, whereas PT-141 is longer as it has a length of 7 amino acids. Argireline is made up of a sequence of Glutamic acid, Glutamic acid, Methionine, Glutamine, Arginine, Arginine. PT-141 is made up of a sequence of sequence data not available in the current dataset.
Argireline
Not assigned in the current dataset.
PT-141
POMC
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