Comparison
While Argireline is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner49, LL-37 acts as a broad-spectrum antimicrobial and immunomodulatory peptide involved in host defense and wound repair, but can also promote inflammation and cancer cell proliferation in some contexts5215.
While Argireline works as acetyl hexapeptide-8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-NH2), a SNAP-25–mimetic peptide that competitively inhibits SNARE complex assembly, reducing acetylcholine release at neuromuscular junctions and attenuating facial muscle contraction4959, LL-37 is a cationic amphipathic 37-amino-acid cathelicidin peptide generated from hCAP18 that disrupts microbial membranes and modulates innate immunity, including chemotaxis, cytokine induction, and NET formation521586.
Argireline is 6 amino acids long, whereas LL-37 is longer as it has a length of 37 amino acids. Argireline is made up of a sequence of Glutamic acid, Glutamic acid, Methionine, Glutamine, Arginine, Arginine. LL-37 is made up of a sequence of Leucine, Leucine, Glycine, Aspartic acid, Phenylalanine, Phenylalanine, Arginine, Lysine, Serine, Lysine, Glutamic acid, Lysine, Isoleucine, Glycine, Lysine, Glutamic acid, Phenylalanine, Lysine, Arginine, Isoleucine, Valine, Glutamine, Arginine, Isoleucine, Lysine, Aspartic acid, Phenylalanine, Leucine, Arginine, Asparagine, Leucine, Valine, Proline, Arginine, Threonine, Glutamic acid, Serine.
Argireline
Molecular target is the SNARE complex component SNAP-25 rather than a classical receptor; it interferes with SNAP-25 participation in vesicle fusion49
LL-37
Argireline
Not assigned in the current dataset.
LL-37
CAMP
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