Comparison
While AOD-9604 is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115, Snap-8 is a cosmetic peptide studied for reducing wrinkle depth by inhibiting synaptic vesicle fusion and subsequent muscle contraction in facial expression muscles5060.
While AOD-9604 works as a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111, Snap-8 is acetyl octapeptide-3 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2), an extended analog of Argireline derived from the N-terminal region of SNAP-25 that competes with native SNAP-25 for binding to syntaxin-1, forming a non-functional SNARE complex and reducing neurotransmitter release5060.
AOD-9604 is 16 amino acids long, whereas Snap-8 is shorter as it has a length of 8 amino acids. AOD-9604 is made up of a sequence of Tyrosine, Leucine, Arginine, Isoleucine, Valine, Glutamine, Cysteine, Arginine, Serine, Valine, Glutamic acid, Glycine, Serine, Cysteine, Glycine, Phenylalanine. Snap-8 is made up of a sequence of Glutamic acid, Glutamic acid, Methionine, Glutamine, Arginine, Arginine, Alanine, Aspartic acid.
AOD-9604
GH1
Snap-8
Not assigned in the current dataset.
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