Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While AOD-9604 is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115, Matrixyl is a widely used cosmetic peptide with evidence of stimulating extracellular matrix synthesis and reducing wrinkle appearance in skin-care formulations48.
While AOD-9604 works as a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111, Matrixyl is a palmitoylated pentapeptide, Pal-Lys-Thr-Thr-Lys-Ser (Pal-KTTKS), that acts as a matrikine, signaling to dermal fibroblasts to increase production of collagen, elastin, fibronectin, and other ECM components4858.
AOD-9604
GH1
Matrixyl
Not assigned in the current dataset.
AOD-9604 and Matrixyl are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: AOD-9604 is more often discussed in the realm of Metabolic and endocrine, whereas Matrixyl is more often associated with the realm of Dermatology and aesthetics. Their biological logic is quite different: AOD-9604 is a hormone analog, whereas Matrixyl is a matrix remodeling modulator. AOD-9604 has a more synthetic analog origin, while Matrixyl is closer to synthetic design background and their development context also differs, with AOD-9604 in Preclinical development while Matrixyl is cosmetic grade. AOD-9604 takes the form of a linear peptide, whereas Matrixyl is closer to a peptide conjugate, Matrixyl incorporates palmitoylation features that are not part of AOD-9604; while their sequence patterns also diverge, with AOD-9604 showing hydrophobic domain features and Matrixyl showing protein-mimetic sequence features.
No related articles are linked to these peptides yet.