Comparison
While AOD-9604 is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials71111115, Ipamorelin is investigated for producing moderate, physiologic-like GH pulses useful for studying anabolic, body-composition, and recovery effects with a relatively clean endocrine side-effect profile compared with earlier GHRPs16.
While AOD-9604 works as a synthetic fragment of human growth hormone corresponding to residues 176–191 with an added N-terminal tyrosine, retaining lipolytic but not growth-promoting actions; proposed to stimulate lipolysis and inhibit lipogenesis in adipose tissue, partly via β3-adrenergic pathways without significantly activating the full GH receptor–IGF-1 axis6171111, Ipamorelin is a third-generation pentapeptide growth hormone secretagogue that selectively agonizes the ghrelin (GHSR-1a) receptor to trigger controlled, GH-specific pituitary release with minimal effects on cortisol or prolactin16269596.
AOD-9604 is 16 amino acids long, whereas Ipamorelin is shorter as it has a length of 5 amino acids. AOD-9604 is made up of a sequence of Tyrosine, Leucine, Arginine, Isoleucine, Valine, Glutamine, Cysteine, Arginine, Serine, Valine, Glutamic acid, Glycine, Serine, Cysteine, Glycine, Phenylalanine. Ipamorelin is made up of a sequence of Aib, Histidine, D-2-Nal, Phenylalanine, Lysine.
AOD-9604
GH1
Ipamorelin
GHSR