Comparison

Acetyl tetrapeptide-5 vs Snap-8

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Snap-8 is a cosmetic peptide studied for reducing wrinkle depth by inhibiting synaptic vesicle fusion and subsequent muscle contraction in facial expression muscles5060.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Snap-8 is acetyl octapeptide-3 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-NH2), an extended analog of Argireline derived from the N-terminal region of SNAP-25 that competes with native SNAP-25 for binding to syntaxin-1, forming a non-functional SNARE complex and reducing neurotransmitter release5060.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas Snap-8 is longer as it has a length of 8 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. Snap-8 is made up of a sequence of Glutamic acid, Glutamic acid, Methionine, Glutamine, Arginine, Arginine, Alanine, Aspartic acid.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

Snap-8

Targets the SNARE complex (SNAP-25–syntaxin interaction) rather than a cell-surface receptor5060

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

Snap-8

Fully synthetic SNAP-25–derived peptide used in topical anti-wrinkle products5060

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

Snap-8

Not assigned in the current dataset.

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
50SNAP-8 (Acetyl Octapeptide-3) Peptide Overview - Kimera Chems, https://kimerachems.co/product/snap-8-acetyl-octapeptide-3/
60SNAP-8 (Acetyl Octapeptide-3): The Topical Anti-Wrinkle | FormBlends, https://formblends.com/research/specialty/snap8-anti-aging-peptide