Comparison

Acetyl tetrapeptide-5 vs Kisspeptin

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, Kisspeptin is a key regulator of the hypothalamic–pituitary–gonadal axis, controlling puberty and fertility; kisspeptin-10 also inhibits trophoblast invasion and tumor metastasis in experimental models339199.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, Kisspeptin is a family of peptides (eg, kisspeptin-10, -13, -14, -54) derived from the KISS1 precursor that activate G-protein–coupled receptor KISS1R (GPR54), triggering GnRH release and regulating pubertal onset and reproductive axis activity339199.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas Kisspeptin is longer as it has a length of 10 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. Kisspeptin is made up of a sequence of Tyrosine, Asparagine, Tryptophan, Asparagine, Serine, Phenylalanine, Glycine, Leucine, Arginine, Tyrosine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

Kisspeptin

KISS1R (GPR54) kisspeptin receptor33919943

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

Kisspeptin

Endogenous human peptide products of the KISS1 gene9199

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

Kisspeptin

KISS1

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
70Kisspeptin-10, rat, https://pubchem.ncbi.nlm.nih.gov/compound/Kisspeptin-10_-rat
91Kisspeptin - Wikipedia, https://en.wikipedia.org/wiki/Kisspeptin
99Kisspeptin-1 - an overview, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/kisspeptin-1