Comparison

Acetyl tetrapeptide-5 vs GHRP-6

Function

While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, GHRP-6 is used experimentally to produce strong GH surges and hyperphagia, allowing investigation of GH-dependent anabolism and energy-balance regulation2030.

Mechanism

While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, GHRP-6 is a first-generation synthetic hexapeptide ghrelin mimetic that potently stimulates GH release and markedly increases appetite via GHSR-1a activation in hypothalamus and pituitary203096.

Length and Sequence

Acetyl tetrapeptide-5 is 4 amino acids long, whereas GHRP-6 is longer as it has a length of 6 amino acids. Acetyl tetrapeptide-5 is made up of a sequence of βAla, Histidine, Serine, Histidine. GHRP-6 is made up of a sequence of Histidine, Tryptophan, Alanine, Tryptophan, Phenylalanine, Lysine.

Receptor

Acetyl tetrapeptide-5

Acts as an enzyme inhibitor (eg, ACE-1, glycation-related pathways) rather than via a specific membrane receptor51159

GHRP-6

Ghrelin/growth hormone secretagogue receptor (GHSR-1a) 203096104

Organism or Origin

Acetyl tetrapeptide-5

Fully synthetic cosmetic peptide (Eyeseryl) 150157

GHRP-6

Synthetic peptide analog of met-enkephalin30

Gene

Acetyl tetrapeptide-5

Not assigned in the current dataset.

GHRP-6

GHSR

Related articles

No related articles are linked to these peptides yet.

Sources

51[PDF] Acetyl tetrapeptide-5 - SkinMiles, https://skinmiles.com/wp-content/uploads/2017/12/Matriskin-Ingredients.pdf
150The important eye peptide of acetyl tetrapeptide-5 - ChemicalBook, https://www.chemicalbook.com/article/the-important-eye-peptide-of-acetyl-tetrapeptide-5.htm
153Acetyl Tetrapeptide-5 (Eyeseryl) | CAS 820959-17-9 Manufacturer ..., https://www.conscientia-industrial.com/peptides/acetyl-tetrapeptide-5-eyeseryl-cas-820959-17-9
154Bioactive peptides in cosmetic formulations: Review of ..., https://www.sciencedirect.com/science/article/pii/S0196978125001019
157Effects of Peptides in Cosmetics, https://aapep.bocsci.com/resources/cosmetic-peptides.html
159Acetyl tetrapeptide-5 | ACE-1 Inhibitor | MedChemExpress, https://www.medchemexpress.com/acetyl-tetrapeptide-5.html
20GHRP-6: The Original GHRP Research Overview - Peptidings, https://peptidings.com/peptides/ghrp-6/
30GHRP-6 - Wikipedia, https://en.wikipedia.org/wiki/GHRP-6
96Growth Hormone Secretagogue Receptor - ScienceDirect.com, https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/growth-hormone-secretagogue-receptor