Acetyl tetrapeptide-5
is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation
Alanine
Ala / A · hydrophobic residue · neutral charge
AOD-9604
is studied as an anti-obesity peptide that can reduce weight gain and increase fat oxidation in obese animal models with generally neutral effects on IGF-1 and glucose metabolism in early human trials
Arginine
Arg / R · basic residue · positive charge
Argireline
is a topical cosmetic peptide reported to decrease dynamic wrinkles by partially mimicking the mechanism of botulinum toxin in a non-invasive manner
Asparagine
Asn / N · polar residue · neutral charge
Aspartic acid
Asp / D · acidic residue · negative charge
BPC-157
is investigated for accelerating healing of gastrointestinal mucosa, tendons, ligaments, bone, and nervous tissue in preclinical models, with anti-inflammatory and pro-angiogenic effects
Comparison
While Acetyl tetrapeptide-5 is used in cosmetic eye formulations to decrease puffiness, eye bags, and dark circles by reducing edema and protecting proteins such as SOD from glycation51150159154, CJC-1295 is used in research to chronically elevate endogenous growth hormone and IGF-1 levels, enabling studies of body composition, metabolic, and anti-aging effects of prolonged GH exposure10.
While Acetyl tetrapeptide-5 works as a synthetic tetrapeptide, Ac-βAla-His-Ser-His (Eyeseryl), with reported ACE-1 inhibition and anti-glycation activity, proposed to improve microcirculation and reduce capillary permeability and fluid accumulation in periorbital tissues51150159157, CJC-1295 is a tetrasubstituted 29-amino-acid analog of GHRH(1–29) that acts as a potent agonist at the GHRH receptor and, in its DAC form, covalently binds serum albumin to extend half-life from minutes to days, resulting in sustained pulsatile GH and IGF-1 increase1082.
Acetyl tetrapeptide-5
Not assigned in the current dataset.
CJC-1295
GHRH
Acetyl tetrapeptide-5 and CJC-1295 are noticeably different, with limited direct overlap in their usual biological context. Their typical research and application settings separate fairly clearly: Acetyl tetrapeptide-5 is more often discussed in the realm of Dermatology and aesthetics, whereas CJC-1295 is more often associated with the realm of Metabolic and endocrine and Aging and longevity. They also influence different molecular systems, with Acetyl tetrapeptide-5 tracking more closely to Extracellular matrix proteins while CJC-1295 centers more on Growth hormone axis. Acetyl tetrapeptide-5 has a more synthetic design origin, while CJC-1295 is closer to synthetic analog background and their development context also differs, with Acetyl tetrapeptide-5 cosmetic grade while CJC-1295 is in Preclinical development. Acetyl tetrapeptide-5 takes the form of a linear peptide, whereas CJC-1295 is closer to a peptide conjugate, while Acetyl tetrapeptide-5 carries acetylation features, while CJC-1295 instead reflects d-amino acid substitution changes.